1-MNA is a breakthrough molecule that works at the cellular level to reduce inflammation and enhance recovery. Thanks to our partnership with European researchers, the dietary supplement Endotelio 1-MNA is now accessible in the US market. Researched extensively for its safety profile, 1-MNA supplementation aims to safely restore NAD levels, optimize cellular redox pathways, and combat age-related diseases comprehensively. Simply put, unlike other NAD supplements, 1-MNA offers a safe and effective way to restore NAD levels for health while maintaining Redox homeostasis. With its high safety profile, 1-MNA is perfect for everyday use to maintain health or can be used to address inflammatory and metabolic disorders.
1-MNA, short for 1-methyl nicotinamide, is a natural compound produced in the body through the breakdown of niacin, a form of vitamin B3. Research indicates that supplementing with 1-MNA can offer benefits for inflammatory conditions, oxidative stress-related issues, and overall health. It aids in reducing inflammation, improving recovery, and safeguarding against cardiac disorders. By regulating mitochondrial function, 1-MNA helps maintain energy balance and promotes bodily equilibrium, making it beneficial for many age-related health conditions such as obesity, metabolic syndrome, cardiac disease, liver disease, cancer, and post-COVID fatigue.
As we age, our body’s ability to produce NAD decreases, leading to a decline in levels of the coenzymes NAD+ and NADP+, which are crucial for cellular processes. This decline starts around age 30, with NAD+ levels dropping by up to 50% between ages 40 and 60. Lower NAD+ levels result in slower cell regeneration and contribute to the aging process. 1-MNA effectively restores healthy NAD+ levels by inhibiting the nicotinamide N-methyltransferase (NNMT) enzyme. Additionally, it enhances the activity of SIRT1 and NRF2, reduces oxidative stress, and blocks inflammation by inhibiting Nuclear factor kappa beta (NF-?B).
