Many of you have seen excellent results in maintaining normal cholesterol levels with time-release niacin. Controlled Release Technology (CRT) is the latest technology for delivering niacin in a continuous, controlled rate over a 12-14 hour period. Flushing sometimes happens with time-release niacin as there can be fairly large surges of niacin released intermittently over a 6-8 hour period. However, flushing is far less likely with controlled release niacin.As a dietary supplement, take one tablet daily with meals or as directed by your health care practitioner. Sensitive individuals may still require moderate niacin titration.wheat, yeast, soy, gluten, eggs, dairy, artificial colors, flavors, sugars, or preservatives.