SAMe is a naturally occurring metabolite found in the human body as well as in plant and animal foods. SAMe is naturally synthesized in humans from the amino acid methionine in the presence of the cofactors B12 and folate. SAMe is the most active of all methyl donors and has been compared to ATP in its importance for the body.
SAMe is involved in the synthesis of:
It is also the source of methyl groups inside the nucleus for DNA methylation which controls gene expression and masking of genetic damage.
- The hormone melatonin
- Polyamines, which control cellular growth
Suggestions: As a dietary supplement, take one tablet one to two times daily, preferably on an empty stomach, or as directed by your health care practitioner. Individuals with bipolar (manic) depression should not take SAMe unless under professional medical supervision.wheat, soy, corn, yeast, milk, or gluten.